Manual Muscle Development in Drosophilia (Molecular Biology Intelligence Unit)

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  3. Muscle Development in Drosophilia | Helen Sink | Springer
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The practicum will study the formation of multicellular tubes in vitro, using micropatterns and microfuidics, ans in vivo, using Drosophila and zebrafish embryos. Fellowships 1. Candidates must have a good knowledge of basic laboratory techniques at the Master degree level. The committee of the course will evaluate applications.

Molecular biology

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Online Developmental Biology: Introduction to Drosophila

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Mol Cell 66 4 Promoter shape varies across populations and affects promoter evolution and expression noise. Dual functionality of cis-regulatory elements as developmental enhancers and Polycomb response elements. Genes Dev.

Muscle Development in Drosophilia

Genetic variants regulating expression levels and isoform diversity during embryogenesis. Identification and in silico modeling of enhancers reveals new features of the cardiac differentiation network. Development 23 Methods Mol.

Je, a versatile suite to handle multiplexed NGS libraries with unique molecular identifiers. BMC Bioinformatics 17 1 doi: Corrigendum: Enhancer loops appear stable during development and are associated with paused polymerase. PLoS Comput.

Muscle Development in Drosophilia | Helen Sink | Springer

Next-generation sequencing-based detection of germline L1-mediated transductions. BMC Genomics 17 1 doi: Bioinformatics 31 19 Conservation of transcription factor binding specificities across million years of bilateria evolution. Elife 4 doi: Enhancer loops appear stable during development and are associated with paused polymerase. Coordinated repression and activation of two transcriptional programs stabilizes cell fate during myogenesis. Development 13 Subtle changes in motif positioning cause tissue-specific effects on robustness of an enhancer's activity.


PLoS Genet. Mol Biosyst 9 9 Impact of genomic structural variation in Drosophila melanogaster based on population-scale sequencing. Genome Res. Fragmentation of DNA in a sub-microliter microfluidic sonication device. Lab Chip 12 22 Bioinformatics 28 19 Nat Protoc 7 5 Tissue-specific analysis of chromatin state identifies temporal signatures of enhancer activity during embryonic development. A transcription factor collective defines cardiac cell fate and reflects lineage history. Cell 3 Analyzing transcription factor occupancy during embryo development using ChIP-seq.

Analysis of variation at transcription factor binding sites in Drosophila and humans. Genome Biol. Predicting spatial and temporal gene expression using an integrative model of transcription factor occupancy and chromatin state. The importance of being specified: cell fate decisions and their role in cell biology. Cell 21 22 Combinatorial binding leads to diverse regulatory responses: Lmd is a tissue-specific modulator of Mef2 activity.

Dynamic CRM occupancy reflects a temporal map of developmental progression. Model-based method for transcription factor target identification with limited data. Challenges for modeling global gene regulatory networks during development: insights from Drosophila.

Table of contents

Conservation and divergence in developmental networks: a view from Drosophila myogenesis. Cell 16 2 Dynamic regulation by polycomb group protein complexes controls pattern formation and the cell cycle in Drosophila. Cell 15 6 Cell 14 5 Enhanced function annotations for Drosophila serine proteases: a case study for systematic annotation of multi-member gene families. Gene Divergence in cis-regulatory networks: taking the 'species' out of cross-species analysis. Temporal ChIP-on-chip reveals Biniou as a universal regulator of the visceral muscle transcriptional network. CoCo: a web application to display, store and curate ChIP-on-chip data integrated with diverse types of gene expression data.

Bioinformatics 23 6 A core transcriptional network for early mesoderm development in Drosophila melanogaster.